Abstract Background Carriers of balanced reciprocal chromosomal translocations are at known reproductive risk for offspring with unbalanced genotypes and resultantly abnormal Placemats phenotypes.Once fertilization of a balanced translocation gamete with a normal gamete, the partial monosomy or partial trisomy embryo will undergo abortion, fetal ar
Association between assisted reproductive technology and advanced retinopathy of prematurity
RV Paul Chan1, Yoshihiro Yonekawa1, Margaux A Morrison2,3, Grace Sun1, Ryan K Wong1, Jeffrey M Perlman4, Michael F Chiang5,6, Foundation Thomas C Lee7, M Elizabeth Hartnett3, Margaret M DeAngelis2,31Department of Ophthalmology, Weill Cornell Medical College, New York; 2Ocular Molecular Genetics Institute, Massachusetts Eye and Ear Infirmary, Harvar
Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1
Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K).Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient carrying the N588K mutation and patch clamp to examine the drug effects on hERG channel gating kine
Unveiling and advancing grassland degradation research using a BERTopic modelling approach
Grassland degradation presents overwhelming challenges to biodiversity, ecosystem services, and the socio-economic Placemats sustainability of dependent communities.However, a comprehensive synthesis of global knowledge on the frontiers and key areas of grassland degradation research has not been achieved due to the limitations of traditional scien